“The body needs to be introduced to the allergen first, before it can overreact the next time,” he says. In most cases, someone who will have such a severe allergic reaction will have been exposed to the allergen at least once before, Baginski says. Ultimately, if left untreated, anaphylaxis can be fatal. People who go into anaphylaxis may experience a warm, tingly feeling in their hands, feet, face, and/or throat and swelling of the lips, tongue, and upper and lower airways, which can cause wheezing and difficulty breathing, changes in pulse and heart rate, dizziness, or fainting. This severe, life-threatening reaction is at the far end of a spectrum of allergy symptoms that people may experience, he says. Īnaphylaxis, Baginski explains, is a medical event during which the immune system overreacts to an antigen-in Bridgerton’s case, a bee sting-to the extent that it initiates an over-the-top response to the invading antigen. Though the phenomenon of anaphylaxis had been described earlier, the seminal experiments weren’t reported until nearly 100 years later, in 1902. It would seem that Edmund Bridgerton experienced a severe allergic reaction-called anaphylaxis-to the bee sting, though the medical community of England’s early-19th century Regency era wouldn’t have known to diagnose it as such. Photos by Matthew Modoono/Northeastern University Baginski, Director of Interdisciplinary Affairs and Associate Clinical Professor, and Assistant Clinical Professor in BHS Stephen Clark.
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